Article

miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis

2022-07-22

Abstract excerpt

MicroRNAs (miRNAs) constitute fine tuners of gene expression and are implicated in a variety of diseases spanning from inflammation to cancer. miRNA expression is deregulated in rheumatoid arthritis (RA), however, their specific role in key arthritogenic cells such as the synovial fibroblast (SF) remains elusive. We have shown in the past that the expression of the miR-221/222 cluster is upregulated in RA SFs. Her...

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Literature Corpus work: 8048c7a3-abe5-543e-84d2-2cf5e3cdd152
DOI: 10.1101/2022.07.22.500939

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