Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

28 Jun 2019

Abstract excerpt

Osteoarthritis (OA) is a common, painful disease. Currently OA is incurable, and its etiology largely unknown, partly due to limited understanding of OA as a whole-joint disease. Here we report that two homologous microRNAs, miR-204 and miR-211, maintain joint homeostasis to suppress OA pathogenesis. Specific knockout of miR-204/-211 in mesenchymal progenitor cells (MPCs) results in Runx2 accumulation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to MicroRNA in disease regulation
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31253842
DOI: 10.1038/s41467-019-10753-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progressionPMID 31253842Read ↗

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis developmentSemantic proximity Read ↗

The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targetsSemantic proximity Read ↗

MicroRNAs in Synovial Pathology Associated With OsteoarthritisSemantic proximity Read ↗

The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-related miRNAsSemantic proximity Read ↗

MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritisSemantic proximity Read ↗

The Role of MicroRNAs in the Pathophysiology of OsteoarthritisSemantic proximity Read ↗

miR-17-92 cluster in osteoarthritis: Regulatory roles and clinical utilitySemantic proximity Read ↗

MicroRNAs play a role in chondrogenesis and osteoarthritis (Review)Semantic proximity Read ↗

Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1Semantic proximity Read ↗

MicroRNAs’ Involvement in Osteoarthritis and the Prospects for TreatmentsSemantic proximity Read ↗

Current understanding of osteoarthritis pathogenesis and relevant new approachesSemantic proximity Read ↗

MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challengeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.