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Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis

4 Apr 2018

Abstract excerpt

Mesenchymal TNF signaling is etiopathogenic for inflammatory diseases such as rheumatoid arthritis and spondyloarthritis (SpA). The role of Tnfr1 in arthritis has been documented; however, Tnfr2 functions are unknown. Here, we investigate the mesenchymal-specific role of Tnfr2 in the TnfΔARE mouse model of SpA in arthritis and heart valve stenosis comorbidity by cell-specific, Col6a1-cre-driven gene targeting. We...

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PMID: 29618659
DOI: 10.1172/jci.insight.98864

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