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Article

Proteotype profiling unmasks a viral signalling network essential for poxvirus assembly and transcriptional competence.

Nature microbiology - 1 May 2018

Novy Karel, Kilcher Samuel, Omasits Ulrich, Bleck Christopher Karl Ernst, Beerli Corina, Vowinckel Jakob, Martin Caroline K, Syedbasha Mohammedyaseen, Maiolica Alessio, White Ian, Mercer Jason, Wollscheid Bernd

Abstract excerpt

To orchestrate context-dependent signalling programmes, poxviruses encode two dual-specificity enzymes, the F10 kinase and the H1 phosphatase. These signalling mediators are essential for poxvirus production, yet their substrate profiles and systems-level functions remain enigmatic. Using a phosphoproteomic screen of cells infected with wild-type, F10 and H1 mutant vaccinia viruses, we systematically defined the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29632367
DOI: 10.1038/s41564-018-0142-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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