Article

Tyro3 worsens the clinical course of experimental autoimmune encephalomyelitis in mice and is associated with suppression of interleukin-4.

2024-12-11

Abstract excerpt

Multiple sclerosis is a complex neurological disorder, involving both the adaptive and innate immune system as well as the CNS. The interaction between these systems is complex, and as such there is the potential for MS therapies to have conflicting effects in different tissues. It is therefore critical that in addition to tissue-specific studies, system-wide effects of potential therapeutic pathways are explored....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 801fe330-bfee-547b-be4a-681d1d88d854
DOI: 10.22541/au.173390049.98948428/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tyro3 worsens the clinical course of experimental autoimmune encephalomyelitis in mice and is associated with suppression of interleukin-4.DOI 10.22541/au.173390049.98948428/v1Read

TAM Receptor Signalling and DemyelinationSemantic proximity Read

New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid ArthritisSemantic proximity Read

The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An OverviewSemantic proximity Read

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.Semantic proximity Read

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell SubsetsSemantic proximity Read

Pathogenic mechanisms and experimental models of multiple sclerosis.Semantic proximity Read

Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cellsSemantic proximity Read

TAM Receptor Signaling in Immune HomeostasisSemantic proximity Read

Serum albumin-fused interleukin-10 prevents neuroinflammation by promoting immunoregulation in the secondary lymphoid organs and limiting immune cell infiltration in the spinal cordSemantic proximity Read

Oncostatin M protects against demyelination by inducing a protective microglial phenotype.Semantic proximity Read

Brain tissue-derived autoimmune encephalitis cytokine TSLP primes neuroinflammation by activating JAK2-NLRP3 axisSemantic proximity Read

Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility.Semantic proximity Read