Article

Brain tissue-derived autoimmune encephalitis cytokine TSLP primes neuroinflammation by activating JAK2-NLRP3 axis

2021-09-24

Abstract excerpt

Hyperactivation of NLRP3 inflammasome contributes to the neuroinflammation in autoimmune disorders, but the underlying regulating mechanism remains to be elucidated. We here demonstrate that mice lacking thymic stromal lymphopoietin receptor gene (Tslpr-/-) exhibit significant decreases in experimental autoimmune encephalitis (EAE) score, reduced CD4+ T cells infiltration, and restored expression of myelin basic p...

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Literature Corpus work: d0e9fe28-c0bd-5b26-bb9f-9a2d23ce8d0f
DOI: 10.22541/au.163252319.93085362/v1

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