Article

B cell responses specific for polyomavirus-derived oncoprotein are predictive of Merkel cell carcinoma tumor control

2025-07-24

Abstract excerpt

Merkel cell carcinomas typically arise from clonal integration of the Merkel cell polyomavirus. Immunogenic viral oncoproteins then lead to tumorigenesis. Oncoprotein-specific T cells are essential for anti-MCC immunity, but it is unclear whether B cells promote tumor control. Here, we analyzed the frequency and phenotype of viral oncoprotein-specific and total B cells in 47 blood samples and 19 unmatched tumors f...

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Literature Corpus work: 800e240c-1b1f-5b9e-a5a3-6fb55ef48f1d
DOI: 10.1101/2025.07.22.666002

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