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Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma

3 Jun 2017

Abstract excerpt

Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by early metastases and poor survival. Although MCC is a rare malignancy, its incidence is rapidly increasing in the U.S. and Europe. The discovery of the Merkel cell polyomavirus (MCPyV) has enormously impacted our understanding of its etiopathogenesis and biology. MCCs are characterized by trilinear differentiation, comprising the...

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PMID: 28693804
DOI: 10.1016/j.critrevonc.2017.05.009

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