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Inhibition of skin glucocorticoid synthesis by topical metyrapone administration supports wound healing in diabetic mice

2026-03-10

Abstract excerpt

<h4>Background: </h4> and Purpose: Chronic wounds are a major complication of diabetes mellitus (DM), posing a significant burden on healthcare systems worldwide. Despite advances in the field over the past two decades, the incidence of lower-limb amputations due to diabetes remains high. Persistent hyperglycemia sustains a chronic low-grade inflammation, disrupts hormonal homeostasis, and elevates glucocorticoid...

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Literature Corpus work
a5692e05-4171-5107-a82d-770c9ae38137
DOI
10.22541/au.177314987.71327230/v1
Open publication

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Inhibition of skin glucocorticoid synthesis by topical metyrapone administration supports wound healing in diabetic miceDOI 10.22541/au.177314987.71327230/v1
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