Article

Immunization with Herpes Simplex Virus Nanoparticles Targeting Both Attachment and Fusion Protect Against Infection

2026-04-25

Abstract excerpt

<h4>SUMMARY</h4> Herpes simplex virus 2 (HSV-2) is associated with genital ulcers, neonatal encephalitis, increased risk of HIV infection, and dementia. There is no licensed HSV-2 vaccine. We developed nanoparticles displaying the HSV-2 attachment protein gD and fusion mediation protein complex gH/gL. Immunization of mice and non-human primates elicited high levels of neutralizing antibodies. Vaccination conferre...

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Literature Corpus work: 7fed12ed-591f-5811-a41a-071a1c664045
DOI: 10.64898/2026.04.24.720674

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