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Functional assessment and structural basis of antibody binding to human papillomavirus capsid

17 Dec 2015

Abstract excerpt

Persistent high-risk human papillomavirus (HPV) infection is linked to cervical cancer. Two prophylactic virus-like particle (VLP)-based vaccines have been marketed globally for nearly a decade. Here, we review the HPV pseudovirion (PsV)-based assays for the functional assessment of the HPV neutralizing antibodies and the structural basis for these clinically relevant epitopes. The PsV-based neutralization assay...

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PMID: 26676802
DOI: 10.1002/rmv.1867

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