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Article

Antigenic breadth: a missing ingredient in HSV-2 subunit vaccines?

16 May 2014

Abstract excerpt

The successful human papillomavirus and hepatitis B virus subunit vaccines contain single viral proteins that represent 22 and 12%, respectively, of the antigens encoded by these tiny viruses. The herpes simplex virus 2 (HSV-2) genome is >20 times larger. Thus, a single protein subunit represents 1% of HSV-2's total antigenic breadth. Antigenic breadth may explain why HSV-2 glycoprotein subunit vaccines have...

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PMID: 24837838
DOI: 10.1586/14760584.2014.910121

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