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Article

Systems pharmacology modeling: an approach to improving drug safety.

Biopharmaceutics & drug disposition - 1 Jan 2014

Bai Jane P F, Fontana Robert J, Price Nathan D, Sangar Vineet

Abstract excerpt

Advances in systems biology in conjunction with the expansion in knowledge of drug effects and diseases present an unprecedented opportunity to extend traditional pharmacokinetic and pharmacodynamic modeling/analysis to conduct systems pharmacology modeling. Many drugs that cause liver injury and myopathies have been studied extensively. Mitochondrion-centric systems pharmacology modeling is important since drug...

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PMID: 24136298
DOI: 10.1002/bdd.1871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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