Article

Genome-Wide Mapping of Cisplatin Damaged Gene Loci

2020-07-28

Abstract excerpt

Cisplatin is a DNA targeting anticancer drug, yet its damaged gene loci have remained unclear. In the present work, combining affinity isolation and high throughput sequencing, we genome-widely mapped 17729 gene loci containing platination lesions, which mainly function as enzymes, transcription regulators, transporters and kinases, and of which 445 genes account for 71% of potential gene targets for cancer therap...

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Literature Corpus work: 7341fc9f-2442-5406-b856-681dea413794
DOI: 10.1101/2020.07.27.222752

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