Article
Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.
Oncogene - 5 Jan 2017
Nickerson M L, Witte N, Im K M, Turan S, Owens C, Misner K, Tsang S X, Cai Z, Wu S, Dean M, Costello J C, Theodorescu D
Abstract excerpt
The utility of tumor-derived cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary tumor biology. Here, we sequenced the exomes of 25 bladder cancer (BCa) cell lines and compared mutations, copy number alterations (CNAs), gene expression and drug response to BCa patient profiles in The Cancer Genome Atlas (TCGA). We observed a mutation pattern associated with altered...
Topics
- Antineoplastic Agents
- Biomarkers
- Cell Line, Tumor
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Cluster Analysis
- Computational Biology
- DNA Copy Number Variations
- DNA Methylation
- Exome
- Genomics
- High-Throughput Nucleotide Sequencing