Article

Protein neddylation governs the inflammatory status of healthy and malignant myeloid cells in response to TLR stimulation

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia is an aggressive hematological disease, where cancer cells down-regulate antigen presentation and immune-stimulatory molecules. Here, we show that genetic deletion of protein neddylation rewires the human AML proteome towards an immunogenic phenotype, while suppressing cholesterol biosynthesis. As a result, neddylation-deficient AML cells respond more potently to...

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Literature Corpus work: 7f51778c-cbd0-5356-8b42-685b411bf6e4
DOI: 10.21203/rs.3.rs-9399910/v1

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