Article

Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML

2025-11-11

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by differentiation arrest and uncontrolled proliferation. Differentiation therapy aims to treat AML by de-repressing latent myeloid maturation programs to induce cell cycle arrest and subsequent cell death. This approach is curative in the promyelocytic AML subtype, but has met with limited success in other subtypes. Genes such as LSD1 have emerged as intriguing non-AP...

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Literature Corpus work: b11183bb-754c-5bdf-8bb5-59185a009931
DOI: 10.1101/2025.11.09.687496

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