Article

Psychedelic Therapy: A Primer for Primary Care Clinicians—Mescaline

2026-02-28

Abstract excerpt

<p>Background: Mescaline (3,4,5-trimethoxyphenethylamine) is a classic serotonergic psychedelic with a history of indigenous ceremonial use. There is renewed scientific interest in mescaline due to the potential psychiatric benefits of psychedelic-assisted therapy. Mescaline primarily exerts its psychoactive effects through serotonin-2A (5-HT2A) receptor agonism. Areas of Uncertainty: There is a lack of controlled...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 43517db3-d5ad-5f74-9ca0-dda1d69366aa
DOI: 10.31234/osf.io/24dwb_v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Psychedelic Therapy: A Primer for Primary Care Clinicians—MescalineDOI 10.31234/osf.io/24dwb_v1Read

Psychedelic Therapy: A Primer for Primary Care Clinicians – Part IV. PsilocybinSemantic proximity Read

Psychedelic Therapy: A Primer for Primary Care Clinicians – Part III. N,N-dimethyltryptamine (DMT) and AyahuascaSemantic proximity Read

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Clinical Trial to Verify the Efficacy and Safety of Ansofaxine (LY03005) for Major Depressive DisorderSemantic proximity Read

Increased 5-HT <sub>2A</sub> receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelicsSemantic proximity Read

The selective 5-HT <sub>2A</sub> receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodentsSemantic proximity Read

5-HT3 receptors: potential of individual isoforms for personalised therapySemantic proximity Read

Do no harm: a paradigm shift in the unchecked use of antidepressants.Semantic proximity Read

A dual-receptor model of serotonergic psychedelicsSemantic proximity Read

5-methoxy-N,N-dimethyltryptamine: An ego-dissolving endogenous neurochemical catalyst of creativitySemantic proximity Read

Doxepin Drug-Drug and Drug-Gene Interactions: Clinical Implications and Mechanistic InsightsSemantic proximity Read

Understanding the role of serotonin in psychiatric diseasesSemantic proximity Read

The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT) Guidelines: An international Delphi consensus studySemantic proximity Read