Article

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells

2019-01-09

Abstract excerpt

Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to explore in liver cells the interconnectedness between three of them, LXR, FXR, and PPARα, all three known to act on lipid and glucose metabolism, and also on inflammation. The hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f003daf-12ec-57b3-b83d-438042f03dd7
DOI: 10.1101/514976

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cellsDOI 10.1101/514976Read

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver diseaseSemantic proximity Read

Nuclear receptors: pathophysiological mechanisms and drug targets in liver diseaseSemantic proximity Read

The emerging roles of liver X receptors and their ligands in cancerSemantic proximity Read

Comparative Transcriptional Network Modeling of Three PPAR-α/γ Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human HepatocytesSemantic proximity Read

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and HumanSemantic proximity Read

New perspectives on PPAR, VDR and FXRα as new actors in testicular pathophysiologySemantic proximity Read

Safety Implications of Modulating Nuclear Receptors: A Comprehensive Analysis from Non-Clinical and Clinical PerspectivesSemantic proximity Read

Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks.Semantic proximity Read

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.Semantic proximity Read

The Interface between Cell Signaling Pathways and Pregnane X ReceptorSemantic proximity Read

Clustering Nuclear Receptors in Liver Regeneration Identifies Candidate Modulators of Hepatocyte Proliferation and HepatocarcinomaSemantic proximity Read

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human HepatocytesSemantic proximity Read