Article
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews - 1 Dec 2006
Michalik Liliane, Auwerx Johan, Berger Joel P, Chatterjee V Krishna, Glass Christopher K, Gonzalez Frank J, Grimaldi Paul A, Kadowaki Takashi, Lazar Mitchell A, O'Rahilly Stephen, Palmer Colin N A, Plutzky Jorge, Reddy Janardan K, Spiegelman Bruce M, Staels Bart, Wahli Walter
Abstract excerpt
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand- and cofactor-binding domain. Many cellular and systemic roles have been attributed to these receptors, reaching far beyond the...
Topics
- Animals
- Binding Sites
- Fatty Acids, Unsaturated
- Humans
- Hypoglycemic Agents
- Ligands
- Mutation
- Peroxisome Proliferator-Activated Receptors
- Pioglitazone
- Protein Isoforms
- Thiazolidinediones