Article

Glucocorticoid receptor alpha: origins and functions of the master regulator of homeostatic corrections in health and critical illness

2025-03-28

Abstract excerpt

The glucocorticoid receptor alpha (GRα), a vital component of the ancient glucocorticoid (GC) signaling system, is essential for vertebrate survival. It regulates fertility, fetal development, organ function, vascular and neural integrity, metabolism, immune responses, and stress adaptation. While GRα’s anti-inflammatory properties have been acknowledged since the mid-20th century, its crucial role as the master r...

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Literature Corpus work: bfbbe0eb-19c7-539f-9198-7ddb10b1f814
DOI: 10.37349/eemd.2025.101426

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