Article

Evaluation of the effects of oncolytic vaccinia virus on colorectal liver metastases in cell lines and in organotypic cultures

2019-01-01

Abstract excerpt

Vaccinia virus is one of several live viruses currently being evaluated in clinical trials as cancer therapies. One oncolytic virus, T-VEC, is already in clinical use and is NICE approved for the treatment of melanoma. We have investigated a genetically modified, Copenhagen strain vaccinia virus encoding the fusion suicide gene (FCU1) that is able to convert non-toxic fluorocytosine into the active compound fluoro...

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Literature Corpus work: 7ed3cf78-8edf-5358-97ff-17142f22596c
DOI: 10.15126/thesis.00850720

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