Article

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells

2024-02-06

Abstract excerpt

DEAD box helicases DDX17 and DDX5 control the termination of transcription and the associated cleavage of the 3’ end of transcripts. Here we show that the transcriptional readthrough induced by their depletion in neuroblastoma cells also results in increased production of chimeric transcripts from tandemly oriented genes. Analysis of neuroblastoma tumours in which chimeric transcripts are abundant revealed that lo...

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Literature Corpus work: 1c96836f-54f7-503d-8036-9376f06efd3f
DOI: 10.1101/2024.02.05.578895

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