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Article

Host ESCRT Proteins Are Required for Bromovirus RNA Replication Compartment Assembly and Function

6 Mar 2015

Abstract excerpt

Positive-strand RNA viruses genome replication invariably is associated with vesicles or other rearranged cellular membranes. Brome mosaic virus (BMV) RNA replication occurs on perinuclear endoplasmic reticulum (ER) membranes in ~70 nm vesicular invaginations (spherules). BMV RNA replication vesicles show multiple parallels with membrane-enveloped, budding retrovirus virions, whose envelopment and release depend...

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PMID: 25748299
DOI: 10.1371/journal.ppat.1004742

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