Article

MOSAIC: A Spectral Framework for Integrative Phenotypic Characterization Using Population-Level Single-Cell Multi-Omics

2026-02-12

Abstract excerpt

Population-scale single-cell multi-omics offers unprecedented opportunities to link molecular variation to human health and disease. However, existing methods for single-cell multi-omics analysis are either cell-centric, prioritizing batch-corrected cell embeddings that neglect feature relationships, or feature-centric, imposing global feature representations that overlook inter-sample heterogeneity. To address th...

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Literature Corpus work: f1132cd2-53fc-5f82-acd3-762497c3851a
DOI: 10.64898/2026.02.10.705077

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