Article

Investigating Genetic and Familial Risks in Childhood ALL: A Longitudinal Virtual Study Using aiHumanoid Simulations of TEL-AML1 Gene Fusion

2024-06-20

Abstract excerpt

Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer, presenting significant challenges in early diagnosis and effective treatment. Recent advances in gene profiling have identified a pivotal role for the TEL-AML1 (ETV6-RUNX1) gene fusion, present in about one quarter of pediatric ALL cases. This gene fusion is often associated with a more benign course and requires additional genetic abnormaliti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e6411cc-8654-575c-8a31-78ea456751ec
DOI: 10.1101/2024.06.19.24309162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Investigating Genetic and Familial Risks in Childhood ALL: A Longitudinal Virtual Study Using aiHumanoid Simulations of TEL-AML1 Gene FusionDOI 10.1101/2024.06.19.24309162Read

Genotype- and Age-Specific Relapse Dynamics in Childhood Acute Lymphoblastic Leukemia: A Longitudinal Mechanistic StudySemantic proximity Read

In Silico Trial Simulation with Artificial Intelligence-Generated Synthetic Control Cohorts Reproduces Results of a Randomized Controlled Trial in Acute Myeloid LeukemiaSemantic proximity Read

Initiating and Cancer-Propagating Cells in <i>TEL-AML1</i> -Associated Childhood LeukemiaSemantic proximity Read

Functionalist Oncology to Model the Contextuality of Dynamics and Treatment in Acute Myeloid LeukemiaSemantic proximity Read

Clustering of childhood acute leukemia in Finland: a nationwide register-based studySemantic proximity Read

Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemiaSemantic proximity Read

A computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapseSemantic proximity Read

Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion.Semantic proximity Read

Explainable Generative AI Uncovers a Molecular Continuum in Medulloblastoma with Implications for Rare Cancer Subtyping and Treatment EquitySemantic proximity Read

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Semantic proximity Read

Mimicking Clinical Trials with Synthetic Acute Myeloid Leukemia Patients Using Generative Artificial IntelligenceSemantic proximity Read