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Article

Initiating and Cancer-Propagating Cells in <i>TEL-AML1</i> -Associated Childhood Leukemia

17 Jan 2008

Abstract excerpt

Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic...

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Identifiers

PMID: 18202291
DOI: 10.1126/science.1150648

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