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Article

Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

11 Dec 2014

Abstract excerpt

Cancer is a clonal evolutionary process, caused by successive accumulation of genetic alterations providing milestones of tumor initiation, progression, dissemination, and/or resistance to certain therapeutic regimes. To unravel these milestones we propose a framework, tumor evolutionary directed graphs (TEDG), which is able to characterize the history of genetic alterations by integrating longitudinal and...

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PMID: 25496728
DOI: 10.7554/elife.02869

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