Article

Telomerase Activity in Melanoma: Impact on Cancer Cell Proliferation Kinetics, Tumor Progression, and Clinical Therapeutic Strategies—A Scoping Review

2025-12-09

Abstract excerpt

Melanoma survival has improved markedly in the past decade with new systemic agents. A key molecular hallmark is aberrant telomerase activation, largely driven by telomerase reverse transcriptase (TERT) promoter mutations (which are present in 50–82% of cases). These mutations represent the most frequent noncoding alteration in melanoma. Telomerase activation results in replicative immortality by maintaining telom...

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Literature Corpus work: 7e63b8ab-a04e-5a0c-809e-f75ff198b30e
DOI: 10.20944/preprints202512.0695.v1

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