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Article

Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment.

Archives of toxicology - 1 Nov 2025

Cho Eunnara, Baird Stephen D, Eccles Kristin M

Abstract excerpt

Cell Painting visualizes toxicity-induced morphological changes by staining cellular structures with fluorescent dyes. Coupled with high-content imaging and analysis software, Cell Painting allows high-throughput phenotypic profiling (HTPP) to quantify phenotypic changes and estimate points of departure for toxicity assessments. Regulatory agencies have applied HTPP in 384-well plates for chemical hazard...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40874998
DOI: 10.1007/s00204-025-04165-2
PMCID: PMC12477089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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