Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth

24 Apr 2018

Abstract excerpt

Deubiquitinases (DUBs) play essential roles in normal cell proliferation and tumor growth. However, the molecular mechanisms of DUBs on hepatocellular carcinoma (HCC) remains largely unknown. In this study, based on analysis of several HCC datasets, we found that the USP21 gene, which encodes a member of the ubiquitin-specific protease family, is highly amplified and overexpressed in HCCs, with the extent of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Histone Deacetylase Inhibitors Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29706623
DOI: 10.1038/s41419-018-0523-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growthPMID 29706623Read ↗

USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1Semantic proximity Read ↗

Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer DevelopmentSemantic proximity Read ↗

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axisSemantic proximity Read ↗

Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular CarcinomaSemantic proximity Read ↗

Targeting deubiquitinase USP28 for cancer therapySemantic proximity Read ↗

Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatmentSemantic proximity Read ↗

Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36Semantic proximity Read ↗

Comprehensive analysis of ubiquitin‐specific protease 1 reveals its importance in hepatocellular carcinomaSemantic proximity Read ↗

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.Semantic proximity Read ↗

Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinomaSemantic proximity Read ↗

USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1Semantic proximity Read ↗

The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.