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Article

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.

Cell death & disease - 5 Jul 2021

Tian Yu, Tang Bo, Wang Chengye, Wang Yan, Mao Jiakai, Yao Yifan, Gao Zhenming, Liang Rui, Ye Mingliang, Cai Shijie, Wang Liming

Abstract excerpt

Oncogenic ubiquitin-specific protease 22 (USP22) is implicated in a variety of tumours; however, evidence of its role and underlying molecular mechanisms in cholangiocarcinoma (CCA) development remains unknown. We collected paired tumour and adjacent non-tumour tissues from 57 intrahepatic CCA (iCCA) patients and evaluated levels of the USP22 gene and protein by qPCR and immunohistochemistry. Both the mRNA and...

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Identifiers

PMID: 34226501
DOI: 10.1038/s41419-021-03940-0
PMCID: PMC8257691

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Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.PMID 34226501Read ↗

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