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Article

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c

2 Jun 2022

Abstract excerpt

Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly incurable and has been recognized as the third leading cause of cancer-related deaths worldwide. As a deubiquitinating enzyme, the antitumor effect of ubiquitin-specific peptidase 53 (USP53) has been demonstrated on few malignancies. In this study, we investigated the potential antitumor role of USP53 in HCC. The results...

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PMID: 35654790
DOI: 10.1038/s41389-022-00404-8

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