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A Respiratory Syncytial Virus trailer sequence modulates viral replication and copy-back defective viral genome generation and propagation kinetics

2025-09-24

Abstract excerpt

Copy-back defective viral genomes (cbDVGs) are key inducers of antiviral responses during negative-sense RNA virus infection. Once considered byproducts of in vitro viral replication, cbDVGs have since been detected in clinical specimens and implicated in affecting infection outcomes. The molecular mechanism of cbDVG generation remains unclear, thereby hindering our ability to manipulate cbDVG production during i...

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Literature Corpus work
7deb44f5-29d6-5aed-a7e9-6662c401945c
DOI
10.1101/2025.09.24.678299
Open publication

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A Respiratory Syncytial Virus trailer sequence modulates viral replication and copy-back defective viral genome generation and propagation kineticsDOI 10.1101/2025.09.24.678299
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