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Validation of diverse and previously untraceable Sendai virus copyback viral genomes by direct RNA sequencing

31 Jul 2025

Abstract excerpt

Copyback viral genomes (cbVGs) are truncated viral genomes with complementary ends produced when the negative-sense RNA virus polymerase detaches from the replication template and resumes elongation from the nascent strand. Despite advances in methods to identify cbVGs based on the site of polymerase break and rejoin, PCR-based tools cannot provide full-length sequences of most cbVGs and/or can introduce errors...

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PMID: 40742273
DOI: 10.1128/jvi.00894-25

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