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A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

17 Apr 2019

Abstract excerpt

Defective viral genomes of the copy-back type (cbDVGs) are the primary initiators of the antiviral immune response during infection with respiratory syncytial virus (RSV) both in vitro and in vivo. However, the mechanism governing cbDVG generation remains unknown, thereby limiting our ability to manipulate cbDVG content in order to modulate the host response to infection. Here we report a specific genomic signal...

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PMID: 30995283
DOI: 10.1371/journal.ppat.1007707

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