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Article

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase.

The Journal of biological chemistry - 29 Aug 2008

Matsushima Yuichi, Farr Carol L, Fan Li, Kaguni Laurie S

Abstract excerpt

Mitochondrial DNA helicase, also called Twinkle, is essential for mtDNA maintenance. Its helicase domain shares high homology with helicases from superfamily 4. Structural analyses of helicases from this family indicate that carboxyl-terminal residues contribute to NTP hydrolysis required for translocation and DNA unwinding, yet genetic and biochemical information is very limited. Here, we evaluate the effects of...

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Identifiers

PMID: 18593709
DOI: 10.1074/jbc.M803674200
PMCID: PMC2527111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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