Article

GGA1 interacts with the endosomal Na+/H+ Exchanger NHE6 governing localization to the endosome compartment

2023-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the endosomal Na+/H+ exchanger (NHE6) cause Christianson syndrome (CS), an X-linked neurological disorder. Previous studies have shown that NHE6 functions in regulation of endosome acidification and maturation in neurons. Using yeast two-hybrid screening with the NHE6 carboxyl-terminus as bait, we identify Golgi-associated, Gamma adaptin ear containing, ARF binding protein 1 (GGA1)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dc793ff-cbf1-5bd2-be23-6f0ccdd59b7f
DOI: 10.1101/2023.11.08.565997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GGA1 interacts with the endosomal Na+/H+ Exchanger NHE6 governing localization to the endosome compartmentDOI 10.1101/2023.11.08.565997Read

The Na <sup>+</sup> (K <sup>+</sup> )/H <sup>+</sup> exchanger Nhx1 controls multivesicular body-vacuolar lysosome fusionSemantic proximity Read

Impaired posttranslational processing and trafficking of an endosomal Na+/H+ exchanger NHE6 mutant (Δ(370)WST(372)) associated with X-linked intellectual disability and autism.Semantic proximity Read

Inhibition of sodium/proton exchange by a Rab-GTPase-activating protein regulates endosomal traffic in yeast.Semantic proximity Read

Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant.Semantic proximity Read

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminusSemantic proximity Read

The Endosomal pH Regulator NHE6 is Required for Insulin-Stimulated Glucose Uptake in AdipocytesSemantic proximity Read

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal–lysosomal dysfunctionSemantic proximity Read

Correction of a pathogenic mutation in iPSCs derived from a patient with Christianson syndrome using CRISPR/Cas9 genome editingSemantic proximity Read

The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6Semantic proximity Read

Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formation.Semantic proximity Read

X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities.Semantic proximity Read

A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl-/H+-Exchanger, Causes Early-Onset Neurodegeneration.Semantic proximity Read