Article

TNFR2 mediates pancreatic cancer proliferation, migration, and invasion via the NF‑κB signaling pathway

2023-01-27

Abstract excerpt

<h4>Purpose: </h4> Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant disease with low overall survival; chemotherapy and immunotherapy have limited efficacy. Tumor necrosis factor receptor 2 (TNFR2) contributes to the development and progression of several tumors. In this study, we investigated the clinicopathologic data and outcomes of pancreatic cancer patients and elucidated the molecular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58c48de8-ac34-5423-8a84-2966fc14738a
DOI: 10.21203/rs.3.rs-2494516/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TNFR2 mediates pancreatic cancer proliferation, migration, and invasion via the NF‑κB signaling pathwayDOI 10.21203/rs.3.rs-2494516/v1Read

IL20RB promotes pancreatic cancer progression by activating NF- kB signalling and promoting EMTSemantic proximity Read

Human pan-cancer analysis of the predictive biomarker for the tumor necrosis factor-alpha-induced protein 8-like 2 (TNFAIP8L2)Semantic proximity Read

Integrated analysis of polytranscriptomics reveals TNFSF ligand genes in pancreatic cancer prognosis and immune regulationSemantic proximity Read

Modulation of PRC1 Promotes Anticancer Effects in Pancreatic CancerSemantic proximity Read

Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancerSemantic proximity Read

Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic GenesSemantic proximity Read

VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.Semantic proximity Read

Blockades Adenosine Receptor 2B Suppresses Pancreatic Adenocarcinoma Progression by Inhibiting Leukemia Inhibitory Factor Secretion from MacrophagesSemantic proximity Read

The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancerSemantic proximity Read

Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migrationSemantic proximity Read

M2-phenotype tumour-associated macrophages upregulate the expression of prognostic predictors MMP14 and INHBA in pancreatic cancer.Semantic proximity Read

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cellsSemantic proximity Read