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Article

Mechanosensitive Ion Channel PIEZO1 as a Key Regulator of Intestinal Fibrosis in Crohn’s Disease

7 Mar 2025

Abstract excerpt

BACKGROUND: We aimed to elucidate the function of the mechanosensitive ion channel PIEZO1 in intestinal fibrosis, which is invariably associated with Crohn's disease (CD) and often results in strictures and obstructions, requiring surgical intervention. Notably, PIEZO1 is strongly expressed in fibrotic tissues and linked with fibrotic progression. METHODS: Intestinal tissues were procured from 28 patients...

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PMID: 40053528
DOI: 10.1093/ibd/izaf041

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