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Article

Impact of negative emotions and insomnia on sepsis: A mediation Mendelian randomization study.

Computers in biology and medicine - 1 Sept 2024

Ni Fengming, Liu Xinmin, Wang Shaokun

Abstract excerpt

BACKGROUND: Negative emotions and insomnia (NEI) can lead to inflammation, which is a characteristic of sepsis. However, the interaction among NEI and sepsis has not yet been proven. Therefore, Mendelian mediation was used to explore this relationship in this study. METHODS: The genetic correlation NEI and sepsis was assessed by via linkage disequilibrium scores (LDSC). A two-sample Mendelian randomization (MR)...

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PMID: 39067155
DOI: 10.1016/j.compbiomed.2024.108858

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