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Article

Does Gastroesophageal Reflux Disease Increase the Risk of Sepsis and Its 28-day Mortality? A Causal Study Using a Mendelian Randomization Approach.

Digestive diseases and sciences - 1 Oct 2024

Zhou Runquan, Li Wenjuan, Wu Fan, Sheng Yuanhui, Xu Shan, Liu Yi, Zhang Dan, Wang Mingxing

Abstract excerpt

BACKGROUND: Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder. Recent studies indicate that GERD may exert systemic effects, potentially elevating the risk of severe infections, including sepsis. Nevertheless, the causal relationship between GERD and sepsis, as well as sepsis-related 28-day mortality, remains uncertain. AIM: The aim of this study is to investigate the causal...

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PMID: 39230635
DOI: 10.1007/s10620-024-08625-0

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