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A Stage-Ordered Multi-Omic Continuum Underlies Cardiovascular-Kidney-Metabolic Syndrome and the Protective Association of Cardiovascular Health

2026-08-13

Abstract excerpt

<h4>Background: </h4> and aims: Cardiovascular-kidney-metabolic (CKM) syndrome stages confer graded CVD risk, but the underlying stage-specific molecular mechanisms remain undefined. <h4>Methods:</h4> In 355,724 UK Biobank participants (median follow-up 13.5 years), we mapped CKM stages (0-3) to incident CVD. Using proteomics (n=37,785) and metabolomics (n=190,112), we identified stage-specific biomarkers via LASS...

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Literature Corpus work
29db37ac-de6c-52af-992d-681e111433e5
DOI
10.64898/2026.08.12.26360091
Open publication

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A Stage-Ordered Multi-Omic Continuum Underlies Cardiovascular-Kidney-Metabolic Syndrome and the Protective Association of Cardiovascular HealthDOI 10.64898/2026.08.12.26360091
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