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Identification of candidate genes encoding tumor-specific neoantigens in early- and late-stage colon adenocarcinoma.

Aging - 10 Jan 2021

Wang Chong, Xue Wenhua, Zhang Haohao, Fu Yang

Abstract excerpt

Colon adenocarcinoma (COAD) is one of the most common gastrointestinal malignant tumors and is characterized by a high mortality rate. Here, we integrated whole-exome and RNA sequencing data from The Cancer Genome Atlas and investigated the mutational spectra of COAD-overexpressed genes to define clinically relevant diagnostic/prognostic signatures and to unmask functional relationships with both...

Topics

Adenocarcinoma
Antigens, Neoplasm
Colonic Neoplasms
Databases, Genetic
Disease-Free Survival
Female
Humans
Male
Mutation
Neoplasm Staging
Prognosis
Survival Rate

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Identifiers

PMID: 33428592
DOI: 10.18632/aging.202370
PMCID: PMC7906157

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