Article

Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells

2023-10-04

Abstract excerpt

Telomeres protect chromosome ends and determine the replication potential of dividing cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core components of telomerase are well-defined, mechanisms of telomerase regulation are still under investigation. We report a novel role for the Src family kinase Fyn, w...

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Literature Corpus work: 7d54e496-120a-5bf8-9a3b-f7c9695258d8
DOI: 10.1101/2023.10.04.560876

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