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Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.

Molecular and cellular biology - 1 Feb 2017

Chiba Kunitoshi, Vogan Jacob M, Wu Robert A, Gill Manraj S, Zhang Xiaozhu, Collins Kathleen, Hockemeyer Dirk

Abstract excerpt

Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase levels are associated with tumorigenesis. Both pathologies can arise from only small perturbation of telomerase function. To analyze telomerase at its low...

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Blotting, Southern
Epitopes
Gene Editing
Human Embryonic Stem Cells
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere Homeostasis

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PMID: 27872149
DOI: 10.1128/MCB.00541-16
PMCID: PMC5247607

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