Article

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal LRR motif for binding interaction partners

2022-09-21

Abstract excerpt

Cilia and flagella associated protein 410 (CFAP410) is a protein localized at the basal body of cilia/flagella and plays essential roles in ciliogenesis. Multiple single amino acid mutations in CFAP410 have been identified in patients. However, the molecular mechanism for how the mutations cause these disorders remains poorly understood due to a lack of high-resolution structures of the protein. Our studies demons...

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Literature Corpus work: 7d0109ae-8419-503d-9f47-6c2fd6c77d4e
DOI: 10.1101/2022.09.21.508879

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