Article

Dramatic reduction in trypanosome motility occurs without large-scale changes to paraflagellar rod ultrastructure

2024-04-19

Abstract excerpt

Eukaryotic flagella - widely conserved structures involved in signalling, metabolism and motility – have a core microtubular axoneme that, in many organisms, is accompanied by prominent extra-axonemal structures. In kinetoplastids, including human parasites such as trypanosomes and Leishmania , a dense filamentous lattice called the paraflagellar rod (PFR) accompanies the axoneme for most of its length. While fun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6535526-2fbe-5b56-aea0-e7e4bdc6b2a0
DOI: 10.1101/2024.04.19.590284

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dramatic reduction in trypanosome motility occurs without large-scale changes to paraflagellar rod ultrastructureDOI 10.1101/2024.04.19.590284Read

The paraflagellar rod of kinetoplastid parasites: From structure to components and functionSemantic proximity Read

Genome-wide subcellular protein map for the flagellate parasite Trypanosoma bruceiSemantic proximity Read

Genome-wide subcellular protein localisation in the flagellate parasite <i>Trypanosoma brucei</i>Semantic proximity Read

FAP20 is required for flagellum assembly in <i>Trypanosoma brucei</i>Semantic proximity Read

Evolutionary adaptations of doublet microtubules in trypanosomatid parasitesSemantic proximity Read

Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella.Semantic proximity Read

CMF70 is a subunit of the dynein regulatory complexSemantic proximity Read

Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1.Semantic proximity Read

A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts.Semantic proximity Read

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanismsSemantic proximity Read

The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian hostSemantic proximity Read

CryoEM structure of the <i>Trypanosoma brucei</i> flagellum central apparatusSemantic proximity Read