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APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei

16 Feb 2021

Abstract excerpt

Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei . The disease disrupts the sleep-wake cycle, leading to coma and death if left untreated. T. brucei motility, transmission, and virulence depend on its flagellum (cilium), which consists of several different specialized subdomains.

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PMID: 33568455
DOI: 10.1128/msphere.01090-20

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