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A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region

2025-05-08

Abstract excerpt

Expression quantitative trait loci (eQTLs) are regulatory variants that affect the expression level of their target genes and have significant impact on disease biology. However, eQTL mapping has been done mostly in one tissue at a time, despite the known prevalence of correlations among tissues. Multivariate analyses incorporating multiple phenotypes are available, but they emphasize linear combinations of phenot...

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Literature Corpus work
7ced2fb7-d9a4-567c-abb1-c414777050c8
DOI
10.1101/2025.05.06.652558
Open publication

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A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC regionDOI 10.1101/2025.05.06.652558
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